Cell-transplantation based therapy is increasingly becoming relevant these days, esp. with a bloom in techniques for stem cell and organoid production. The transplanted cells could greatly benefit treatment of degenerative diseases. But how do the transplants help the diseased organ. The obvious thinking is that they help by providing a fresh supply of healthy cells. But is that always the case?
Tiago and colleagues asked what happens to retinal cells transplanted into a damaged eye. And surprisingly found that the transplanted cells did not integrate into the organ, but rather provided cytoplasmic material to the pre-exisiting host cells. Cytoplasmic material present within the transplanted cells was being taken up by the host cells. This was a clear indication of a new way by which transplants could help the damaged tissue, which could be used to potentially transfer much more cargo in future. To know more, please listen to Tiago.
For further information, please refer to:
Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange.
Santos-Ferreira et al., Nature Communications, 2016
Tiago and colleagues asked what happens to retinal cells transplanted into a damaged eye. And surprisingly found that the transplanted cells did not integrate into the organ, but rather provided cytoplasmic material to the pre-exisiting host cells. Cytoplasmic material present within the transplanted cells was being taken up by the host cells. This was a clear indication of a new way by which transplants could help the damaged tissue, which could be used to potentially transfer much more cargo in future. To know more, please listen to Tiago.
For further information, please refer to:
Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange.
Santos-Ferreira et al., Nature Communications, 2016
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