Monday, August 15, 2016

Piggyback Microbe and Cancer! Interview with Niranjan Nagarajan on role of microbiome in bile duct cancer.

Cancer is a very complex disease, with various genetic and environmental factors playing a role in its development and growth. Mutations within the cell and signaling among cells is well known to play vital roles. But could there be other players involved in the process. Of note, something which surrounds us at all times: our microbiome?

Our body is composed of as many microbiome as our own cells. A lot of it comes from the food we eat and the water we drink. Along with our meals, food related parasites might bring their own microbiome into our body, and these could in turn home into organs and modify the tissue microenviroment. This is what Niranjan and colleagues see for bile duct cancer - in which liver fluke parasite arriving from consumption of raw fish finds a home in the bile duct and increases the chance of developing cancer. Their work emphasizes an appreciation into the role of microbiota in cancer development. To know more, please listen to Niranjan.  



To learn more, please refer to:
Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma
Chng et al., eBioMedicine, June 2016Volume 8, Pages 195–202.

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