Skin is possibly the most commonly injured organ, while heart injury is the most fatal. Our skin, a barrier that protects from the harshness of the outside world, is easily bruised and scratched - remember bumping into table edges; while heart attacks kill more than 15 million people annually. Understanding the development, maintenance and regeneration of these organs would help deal with such calamities better.
Chen-Hui Chen and Matthew Foglia along with their colleagues set out to so. They study zebrafish skin and heart to understand the cellular behaviors in multiple contexts, but they do so with a colorful twist. They transform into cubist artist, like Picasso, and paint the various cells constituting the organ with vibrant colors. This gives each cell its own identity, allowing vivid observations on how the various components of the organ are interacting with each other. Such interactions lets them paint (pun intended) pictures with precise cellular resolution, opening the path for studying a multitude of biological questions. Please listen in to understand the magic and its implications.
To know more, please read the following:
Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish
Chen CH et al., Developmental Cell 2016.
Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium.
Foglia MJ et al., Development 2016.
Introduction and closing remarks by Priyanka Oberoi.
Chen-Hui Chen and Matthew Foglia along with their colleagues set out to so. They study zebrafish skin and heart to understand the cellular behaviors in multiple contexts, but they do so with a colorful twist. They transform into cubist artist, like Picasso, and paint the various cells constituting the organ with vibrant colors. This gives each cell its own identity, allowing vivid observations on how the various components of the organ are interacting with each other. Such interactions lets them paint (pun intended) pictures with precise cellular resolution, opening the path for studying a multitude of biological questions. Please listen in to understand the magic and its implications.
To know more, please read the following:
Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish
Chen CH et al., Developmental Cell 2016.
Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium.
Foglia MJ et al., Development 2016.
Introduction and closing remarks by Priyanka Oberoi.
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