A human body is not only made up of eukaryotic cells, but lives in symbiosis with almost an equal number of bacterial cells. This rich collection of bacteria co-existing with our body is called microbiota. Specifically, the gut microbiota - bacteria living in our intestines -find insights into the relationship are of special importance since they can shape metabolism, mood and susceptibility to diseases. How is this colony of bacteria regulated forms the basis of this two-part podcast.
In the first part, we talk about the effects antibiotics could have on microbiota. The Microbiota is set up at birth. In kids, the microbiota is highly dynamic, and settles into stable colony by adulthood. What happens when the process of microbiota formation is afflicted by antibiotic usage. Does it ever recover back to normalcy following antibiotic exposure. Katri Korpela and colleagues set out to study the long term relation between antibiotics and microbiota in Finnish pre-school children. Listen in to find insights into the relationship.
In second part, we talk to Shirong Liu who along with his colleagues found the communication device used by our body to stabilize microbiota colony. Microbiota stays stable over long periods of time in adult individuals, and they looked at the role played by miRNA in the process. miRNA are small RNA molecules that regulate gene expression. Liu and colleagues found that our body uses miRNA to shape the microbiota diversity and such miRNA can be detected in fecal samples. This interesting finding opens the door to non-invasive diagnostic devices to look at health and composition of microbiota. Please listen in to find more!!
To know more, please refer to the following articles:
First part (Antibiotics and microbiota):
Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children
Katri Korpela et al., Nature Communications 7, Jan 2016
Second part (Regulation by Fecal miRNA):
The Host Shapes the Gut Microbiota via Fecal MicroRNA
Shirong Liu et al., Cell Host and Microbes, Volume 19, Issue 1, p32–43, 13 January 2016
Introduction and closing by Priyanka Oberoi.
In the first part, we talk about the effects antibiotics could have on microbiota. The Microbiota is set up at birth. In kids, the microbiota is highly dynamic, and settles into stable colony by adulthood. What happens when the process of microbiota formation is afflicted by antibiotic usage. Does it ever recover back to normalcy following antibiotic exposure. Katri Korpela and colleagues set out to study the long term relation between antibiotics and microbiota in Finnish pre-school children. Listen in to find insights into the relationship.
In second part, we talk to Shirong Liu who along with his colleagues found the communication device used by our body to stabilize microbiota colony. Microbiota stays stable over long periods of time in adult individuals, and they looked at the role played by miRNA in the process. miRNA are small RNA molecules that regulate gene expression. Liu and colleagues found that our body uses miRNA to shape the microbiota diversity and such miRNA can be detected in fecal samples. This interesting finding opens the door to non-invasive diagnostic devices to look at health and composition of microbiota. Please listen in to find more!!
To know more, please refer to the following articles:
First part (Antibiotics and microbiota):
Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children
Katri Korpela et al., Nature Communications 7, Jan 2016
Second part (Regulation by Fecal miRNA):
The Host Shapes the Gut Microbiota via Fecal MicroRNA
Shirong Liu et al., Cell Host and Microbes, Volume 19, Issue 1, p32–43, 13 January 2016
Introduction and closing by Priyanka Oberoi.
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